https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Induction of caspase-mediated apoptosis in HepG2 liver carcinoma cells using mutagen-antioxidant conjugated self-assembled novel carbazole nanoparticles and in silico modeling studies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45243 1H nuclear magnetic resonance, dynamic light scattering (DLS), and transmission electron microscopy techniques. The CT-capped gold nanoparticles (CTAuNPs) were prepared from CT, chloroauric acid, and NaBH₄. The CTAuNPs were characterized using ultraviolet–visible, high-resolution TEM, DLS, and Fourier transform IR techniques. The cytotoxicity and apoptosis-inducing ability of both nanoparticles were determined in HepG2 cells. The results demonstrate that CTNs exhibit antiproliferative activity in the cancerous HepG2 cells. Moreover, molecular docking and molecular dynamics studies were conducted to explore the therapeutic potential of CT against human EGFR suppressor protein to gain more insights into the binding mode of the CT, which may show a significant role in anticancer therapy.]]> Wed 26 Oct 2022 15:56:50 AEDT ]]> Induction of caspase-mediated apoptosis in HepG2 liver carcinoma cells using mutagen-antioxidant conjugated self-assembled novel carbazole nanoparticles and in silico modeling studies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45239 1H nuclear magnetic resonance, dynamic light scattering (DLS), and transmission electron microscopy techniques. The CT-capped gold nanoparticles (CTAuNPs) were prepared from CT, chloroauric acid, and NaBH₄. The CTAuNPs were characterized using ultraviolet–visible, high-resolution TEM, DLS, and Fourier transform IR techniques. The cytotoxicity and apoptosis-inducing ability of both nanoparticles were determined in HepG2 cells. The results demonstrate that CTNs exhibit antiproliferative activity in the cancerous HepG2 cells. Moreover, molecular docking and molecular dynamics studies were conducted to explore the therapeutic potential of CT against human EGFR suppressor protein to gain more insights into the binding mode of the CT, which may show a significant role in anticancer therapy.]]> Wed 26 Oct 2022 15:56:20 AEDT ]]> Targeting eosinophils in respiratory diseases: biological axis, emerging therapeutics and treatment modalities https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46370 Wed 16 Nov 2022 08:45:58 AEDT ]]> Perspectives and advancements in the design of nanomaterials for targeted cancer theranostics https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47141 Wed 14 Dec 2022 15:27:43 AEDT ]]> Advanced drug delivery systems can assist in targeting coronavirus disease (COVID-19): a hypothesis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49602 Tue 23 May 2023 15:26:55 AEST ]]> Targeting LIN28: A new hope in prostate cancer theranostics https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53314 Tue 21 Nov 2023 12:37:09 AEDT ]]> An overview of vaccine development for COVID-19 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46318 Tue 15 Nov 2022 11:45:52 AEDT ]]> Calcium sensing receptor hyperactivation through viral envelop protein E of SARS CoV2: A novel target for cardio-renal damage in COVID-19 infection https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53385 Thu 23 Nov 2023 12:55:23 AEDT ]]> Advanced drug delivery systems can assist in managing influenza virus infection: a hypothesis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38437 Mon 29 Jan 2024 18:01:05 AEDT ]]> Anti-inflammatory and anticancer activities of Naringenin-loaded liquid crystalline nanoparticles in vitro https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49577 Mon 22 May 2023 10:51:01 AEST ]]>